If someone gains a lot of weight and then loses it again, will her body be more resistant to gaining weight again?

 While there is some evidence to suggest that losing weight can make it harder to gain weight back, it is not a guarantee that the body will be more resistant to weight gain in the future.

One factor that can affect weight regain is metabolic adaptation. When someone loses weight, their metabolism may slow down, making it easier to regain weight if they return to their previous eating habits. However, this can vary from person to person depending on factors such as age, gender, genetics, and lifestyle habits.

Additionally, weight regain can also be influenced by psychological factors such as stress, emotional eating, and a lack of support or resources for maintaining healthy habits.

While there is no foolproof way to prevent weight regain, maintaining a healthy diet and exercise routine can help reduce the risk. It's also important to approach weight loss and maintenance in a sustainable way, making gradual changes to your lifestyle that you can maintain over the long term. Consulting with a registered dietitian or healthcare provider can also provide helpful guidance and support.